3β,11α-Dihydroxy-17a-oxa-d-homoandrost-5-en-17-one
نویسندگان
چکیده
The title compound, C(19)H(28)O(4), was prepared from DHEA (dehydro-epiandrosterone) by its biotransformation using whole cells of the filamentous fungus Beauveria bassiana. The asymmetric unit contains two mol-ecules. The lactone ring is trans-positioned to the neighboring six-membered ring. In the crystal structure, O-H⋯O hydrogen bonds form layers, which are linked to each other by O-H⋯O and C-H⋯O hydrogen bonds.
منابع مشابه
Baeyer-Villiger oxidation of some C(19) steroids by Penicillium lanosocoeruleum.
The biotransformation of androsterone (1), epiandrosterone (2), androstanedione (3) and DHEA (dehydroepiandrosterone) (4) by Penicillium lanosocoeruleum-a fungal species not used in biotransformations so far-were described. All the substrates were converted in high yield (70%-99%) into D ring δ-lactones. The oxidation of 1 produced 3α-hydroxy-17a-oxa-D-homo-5α-androstan-17-one (5). The oxidatio...
متن کامل3β,11α-Dihydroxy-12-ursen-3-yl palmitate
In the title compound, C(46)H(80)O(3), a natural ursane-type triperpenoid, four of the five six-membered rings adopt chair conformations; the fifth, which has a C=C double bond, adopts an approximate half-boat conformation. In the crystal, mol-ecules are linked by O-H⋯O hydrogen bonds, forming chains along [010].
متن کاملSynthesis and Characterization of 3β-substituted amides of 17a-aza-D- homo-4-androsten-17-one as 5α-Reductase Inhibitors, antimicrobial and antioxidant activities
The study reports the convenient and efficient synthesis of several new analogues of 3β-substituted amides of 17a-aza-Dhomo-4-androsten-17-one (3a-3e) from commercially available Diosgenin as the starting material. The structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and Mass spectrometry. We herein report the 5αreductase inhibitory, antimicrobial and antioxidant ...
متن کامل5α-Reductase Inhibitors, antimicrobial and antioxidant activities of 3β- substituted amides of 17a-aza-D-homo-4-androsten-17-one
The study reports the convenient and efficient synthesis of several new analogues of 3β-substituted amides of 17a-aza-Dhomo-4-androsten-17-one (11a-11d) from commercially available Diosgenin as the starting material. The structures of newly synthesized compounds were confirmed by IR, H NMR, C NMR and mass spectrometry. We herein report the 5α-reductase inhibitory, antimicrobial and antioxidant ...
متن کاملNew Bufadienolides Isolated from the Roots of Kalanchoe daigremontiana (Crassulaceae).
An aqueous extract from the roots of Kalanchoe daigremontiana turned out to be a rich source of bufadienolides. The existing literature data relate mainly to the aerial parts of Kalanchoe but there is no information about the metabolic profile of the roots, which are also used in traditional medicine. Our investigation concerning the roots of K. daigremontiana led to the isolation and character...
متن کامل